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Rimstar 4 should not be given during pregnancy unless the potential benefit justifies the potential risk to the fetus.
Administration of rifampicin during the last few weeks of pregnancy can cause postnatal hemorrhage in the mother and newborn infant. This may necessitate treatment with vitamin K preparations. Although rifampicin, isoniazid, pyrazinamide and ethambutol pass into breast milk, no adverse effects on breastfed infants have been observed.
Since it is theoretically possible that isoniazid might exert neurotoxic effects on the child, prophylactic administration of pyridoxine to the mother during pregnancy and to the mother and child during breastfeeding is recommended.
